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Research

Bronchopulmonary dysplasia: Rationale for a pathophysiological rather than treatment based approach to diagnosis

This review describes the evolution of bronchopulmonary dysplasia definitions, evaluates the benefits and limitations of each approach

Research

Laryngeal reflex responses in pediatric anesthesia

Laryngeal and respiratory reflexes are vitally important defense mechanisms against foreign body aspiration, safeguarding airway patency, and ventilation

Research

Association between diesel engine exhaust exposure and lung function in Australian gold miners

Diesel engine exhaust exposures were higher in underground miners and had a negative association with their lung function over a single 12-h shift

Research

Variants associated with HHIP expression have sex-differential effects on lung function

Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.

Research

Altered lung structure and function in mid-childhood survivors of very preterm birth

To obtain comprehensive data on lung structure and function in mid-childhood from survivors of preterm birth.

Research

Global Lung Function Initiative reference values for multiple breath washout indices

Multiple breath washout is a lung function test based on tidal breathing that assesses lung volume and ventilation distribution. The aim of this analysis was to use the Global Lung Function Initiative methodology to develop all-age reference equations for the multiple breath washout indices lung clearance index and functional residual capacity.

Research

Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis

Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF. 

Research

A wellbeing program to promote mental health in paediatric burn patients: Study protocol

One of the most traumatic injuries a child can experience is a severe burn. Despite improvements in medical treatments which have led to better physical outcomes and reduced mortality rates for paediatric burns patients, the psychological impact associated with experiencing such a traumatic injury has mostly been overlooked. This is concerning given the high incidence of psychopathology amongst paediatric burn survivors. 

Research

Respiratory impedance and bronchodilator responsiveness in healthy children aged 2-13 years

There is limited information on changes in FOT outcomes in healthy children beyond the preschool years and the level of bronchodilator responsiveness (BDR)...

Research

Lung function in African infants: A pilot study

Infant lung function (ILF) testing may provide useful information about lung growth and susceptibility to respiratory disease.