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Fusionfinder: A software tool to identify expressed gene fusion candidates from RNA-seq data
The hallmarks of many haematological malignancies and solid tumours are chromosomal translocations, which may lead to gene fusions.
Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2
In T-cell acute lymphoblastic leukemia (T-ALL) cytogenetic alterations juxtapose the LIM-domain-only-2 gene (LMO2) with T-cell receptor loci.
Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines
Glucocorticoids (GCs) are among the most important drugs for the treatment of acute lymphoblastic leukaemia (ALL).
Associate Professor Laurence Cheung
Co-Head, Leukaemia Translational Research
Professor Rishi S. Kotecha
Co-Head, Leukaemia Translational Research
Professor Ursula Kees
Honorary Emeritus Fellow