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Research
Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical TrialTo examine follow-up outcomes at corrected postnatal age (cPNA) 2 years of preterm infants previously enrolled in an RCT and treated with IN-REC-SUR-E or IN-SUR-E in 35 tertiary neonatal intensive care units.
Research
Neonatal high-frequency oscillatory ventilation: where are we now?High-frequency oscillatory ventilation (HFOV) is an established mode of respiratory support in the neonatal intensive care unit. Large clinical trial data is based on first intention use in preterm infants with acute respiratory distress syndrome. Clinical practice has evolved from this narrow population. HFOV is most often reserved for term and preterm infants with severe, and often complex, respiratory failure not responding to conventional modalities of respiratory support.
The Chronobiology team works to understand the factors that contribute to poor lung and heart function in newborn infants and find ways to prevent heart and lung disease.
Research
Interleukin-4 modulates type I interferon to augment antitumor immunityDespite advances in immunotherapy, metastatic melanoma remains a considerable therapeutic challenge due to the complexity of the tumor microenvironment. Intratumoral type I interferon (IFN-I) has long been associated with improved clinical outcomes. However, several IFN-I subtypes can also paradoxically promote tumor growth in some contexts.
Research
Simplified bedside assessment of pulmonary gas exchange in very preterm infants at 36 weeks' postmenstrual ageWe aimed to develop and validate a prediction table for a simplified measure of rightward shift of the fetal oxyhaemoglobin saturation (SpO2) versus inspired oxygen pressure (P IO2) curve as an objective marker of lung disease severity in very preterm infants, independent of unit altitude or oxygen prescribing policies.
Meet the team behind the CIRCA DIEM study.
A sub-study is an ‘add-on’ study that helps to answer specific questions within a larger research project. If you decide to participate in the CIRCA DIEM study, you or your child may be invited to take part in one of the CIRCA DIEM sub-studies.
The CIRCA DIEM study aims to establish if cycling environmental light and noise levels for premature infants during their initial hospital stay leads to earlier development of circadian (daily) rhythms and better outcomes for the preterm babies, including improved brain development.