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Confounding effects of gavage in mice: Impaired respiratory structure and functionIt is therefore clear that gavage can have significant impacts on experimental animals in terms of their stress response and overall morbidity and mortality
Research
Mechanical Abnormalities of the Airway Wall in Adult Mice After Intrauterine Growth RestrictionWe propose that mechanical abnormalities of the airway wall acquired through disrupted fetal growth impact susceptibility to disease
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Nicotine and other potentially harmful compounds in "nicotine-free" e-cigarette liquids in AustraliaThe aim of our investigation was to assess the chemical composition of a range of e-liquids available in Australia, focusing on nicotine and other potentially harmful compounds
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Effects of human rhinovirus on epithelial barrier integrity and function in children with asthmaThis study demonstrates novel intrinsic differences in tight junctions gene and protein expression between airway epithelial cells of children with and without asthma
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Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial CellsApically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces.
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Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restrictionThe rat model demonstrates that intrauterine growth restriction leads to a more heterogeneous distribution of airway lumen calibre in adulthood
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Vitamin D supplementation of initially vitamin D-deficient mice diminishes lung inflammation with limited effects on pulmonary epithelial integrityIn disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset.
News & Events
Directing immune development to curb sky-rocketing diseaseOnce upon a time it was infectious diseases like polio, measles or tuberculosis that most worried parents. With these threats now largely under control, parents face a new challenge – sky-rocketing rates of non-infectious diseases such as asthma, allergies and autism.
News & Events
Australian researchers join international project to curb unhealthy lifetime trajectoriesAustralian researchers join global effort to better understand how events during pregnancy and childhood influence the development of disease later in life.
Research
National E-cigarette Monitoring and Evidence Consortium: Supporting informed research, policy and practice in AustraliaAlexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids