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Children with otitis media mount a pneumococcal serotype specific serum IgG and IgA response comparable to healthy controls after pneumococcal conjugate vaccinationWe investigated the suggestion that otitis-prone children have an impaired antibody response in the context of pneumococcal vaccination.
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Genetic susceptibility to otitis media in childhoodReviewed in this article these studies have identified positive association at 21 genes with association at five of these replicated in independent populations.
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IgG Responses to Pneumococcal and Haemophilus Influenzae Protein Antigens Are Not Impaired in Children with a History of Recurrent Acute Otitis MediaVaccines including conserved antigens from Streptococcus pneumoniae & nontypeable Haemophilus influenzae have the potential to reduce of otitis media.
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FBXO11, a regulator of the TGFΒ pathway, is associated with severe otitis media in Western Australian childrenOtitis media (OM) is a common childhood disease characterised by middle ear inflammation following infection
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Predominance of nontypeable haemophilus influenzae in children with otitis mediaIn Australia the 7-valent pneumococcal conjugate vaccine (PCV7) is administered at 2, 4 and 6 months of age, with no booster dose.
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Crowding and other strong predictors of upper respiratory tract carriage of otitis media-related bacteriaStreptococcus pneumoniae, Moraxella catarrhalis, and nontypeable Haemophilus influenzae is associated with otitis media
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Nasopharyngeal carriage of Haemophilus haemolyticus in otitis-prone and healthy childrenHaemophilus haemolyticus is often incorrectly categorized as nontypeable Haemophilus influenzae (NTHI) upon culture. PCR analyses of 266 NTHI-like nasopharyngea
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Topical versus systemic antibiotics for chronic suppurative otitis mediaTo assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media
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Aural toilet (ear cleaning) for chronic suppurative otitis mediaTo assess the effects of aural toilet procedures for people with chronic suppurative otitis media
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Australian Aboriginal children with otitis media have reduced antibody titers to specific nontypeable Haemophilus influenzae vaccine antigensdecreased serum IgG responses to NTHi outer membrane proteins may contribute to the development of chronic and severe OM in Australian Aboriginal children